Increasing degradation of watershed ecosystem is a problem that needs to be resolved. Therefore, a study was conducted in order to determine the socio-economic and biophysical vulnerability of Solo watershed in relation to watershed management. This research was conducted in Solo Watershed. The collected data include primary and secondary data. The potential and vulnerability of socio-economic and biophysical were evaluated using the The Formulation of Watershed level Characterization System. The results of the study showed that (1) the socio-economic of the whole Solo watershed classify as moderate category, with the highest vulnerable district was Wonogiri due to high population density and high land vulnerability, (2) land vulnerability for the whole Solo watershed is in the medium category, with the most vulnerable land category was in Madiun and upstream Solo sub-watersheds, (3) the most prominent flood vulnerability was in the downstream of Solo sub-watershed, (4) the typology of watershed management was classified as high vulnerable because the territorial typology was in the very high vulnerable and the watershed typology was medium vulnerable. By knowing its vulnerability level, the rehabilitation program can be directed to areas with a high level of vulnerability.