Background: Early adolescent is one of the most important transition period at life where there is a change of physical, psychological, and social. Functional dyspepsia (FD) is a disorder of the stomach that is quite common in the community which can become a stressor for early adolescent.Objective: To determine the prevalence of FD, anxiety, depression and relationship between functional dyspepsia with anxiety and depression in early adolescence in Semarang.Methods: This study uses observational analytic with cross sectional study design. Subjects were 210 adolescents aged 10-14 years with dyspepsia from several elementary and junior high schools in Semarang. Subjects were then given informed consent, filled out personal data, filled out the Rome III Functional Dyspepsia questionnaire, Screen for Children Anxiety Related Emotional Disorders, child (SCARED-C) questionnaire and Children's Depression Inventory (CDI) questionnaire. The relationship analysis was calculated using Chi-square test or Fisher's exact test as an alternative test.Results: The prevalence of FD was 2.4%, anxiety was 41.9% and depression was 5.2%. p=0.402 was obtained for relationship between FD with anxiety and p=1.000 for FD with depression. p=0.017 was obtained for relationship between nausea with depression.Conclusions: There was no significant relationship between functional dyspepsia with anxiety and depression. There was a significant relationship between nausea with depression symptom.