Skin cancer as the most common cancer diagnosis tend to be increasing. This condition is a particularly significant issue in developed countries. This study aimed to describe the clinical features, histopathological features, complications, and early surgical treatment outcomes of skin cancer in Can Tho Oncology Hospital from 2014 to 2015. This descriptive prospective study involved all patients with non-melanoma skin cancer that were examined and treated at Can Tho Oncology Hospital from July 2014 to March 2015. There were 78 cases selected. Skin cancer was found to be more common among older patients. The prevalence of basal cell carcinoma was found higher than squamous cell carcinoma with percentage worth 76.9% and 23.1% respectively. Worth 73.1% of all the patients in the study underwent surgery with wide resection and reconstruction. In this study, most patients were the elderly. The basal cell carcinoma was the most common. The main treatment was surgery with wide resection and reconstruction. The complication was rare 1.3% with skin flap necrosis.