Poverty is a fundamental problem in economic development, especially in developing countries like Indonesia. Central Java became one of the provinces that have always had poverty rates above the national level. The analytical method used to determine the factors that affect poverty in Central Java used panel data regression analysis. Estimation was conducted using a random effect model. The coefficient of determination (Adjusted R-square) to model the figure of 0.728 which indicates that the independent variable in the model is able to explain 73 percent of the variation of endogenous variables as well. Meanwhile, 27 percent of the rest is explained by other variables that are outside the model. Education, agricultural productivity and inflation have an impact on poverty reduction. Unemployment and economic growth positive effect on poverty levels.