World Health Organization (WHO) data show that diarrhea is still the number one cause of infant deaths worldwide. In Indonesia, diarrhea is the second most common killer of children under five after ISPA (Acute Respiratory Tract Infection). UNICEF (the United Nations agency on children's affairs) estimates that every 30 seconds one child dies from diarrhea. Every year 100,000 infants in Indonesia die from diarrhea (USAID, 2015). This study aims to determine the correlation between the occurrence of diarrhea with the role of health workers and the availability of clean water facilities in Kelurahan Talang Jawa Working Area UPTD Puskesmas Tanjung Agung 2017. The study used an analytical survey with cross sectional approach. 92 samples are taken from the population using random sampling techniques. The result of chi-square statistic test showed that there was a significant correlation between diarrhea occurrence and the role of health officer with p value = 0,000 (p < 0,05) and availability of clean water with p value = 0,022 (p < 0,05). The result of the research is expected to be input in planning the eradication of diarrhea disease in Kelurahan Talang Jawa Working Area of UPTD Puskesmas Tanjung Agung.