The increasing of clients with diseases that can not be cured in both adults and children such as cancer, degenerative diseases, chronic obstructive pulmonary disease, cystic fibrosis, stroke, Parkinson's, heart failure / heart failure, genetic diseases and infectious diseases such as HIV / AIDS need care and the palliative health services. This review paper discussed published findings from studies on the role and interaction among patients, their families and health workers in End-of-Life (EOL) care and dying of terminally ill patients with various physical health conditions, mental, environment and background. This paper discussed the roles of various stakeholders involved in end-of-life care, including the patients, close relatives and decision makers, and health workers including physicians, nurses, and other health related workers. The purpose of this literature review to provide additional insight into the treatment of terminal patients who face end of life, the family hopes to health care and how health perspective on the issue. The method used is descriptive qualitative. Data collection by conducting in-depth interviews, and observations. Informants consisted of patients, families, and health workers. Setting of the end of life care in a nursing home environment and community hospitals for elderly patients in the palliative care setting. There are three themes that will be found that patients facing end of life, families of patients with terminal illness and health workers in providing care to patients with terminal illness. It is important to improve the quality of the palliative care, especially in the process of death and the end of life in various settings of care.