Background: The consumption of ethanol causes damage to the cerebellum. The damage to the cerebellum includes the reduction of the activity of cerebellar neurons and the number of Purkinje cells. The consumption of etanol also causes the degeneration of endogenous antioxidants. Antioxidants supplements which are capable to penetrate the brain blood barrier include antosianin, polyphenol and flavonoid. The functions of antioxidants include inhibiting apoptosis, restoring neuronal signals, preventing and fighting against oxidative stress, and neutralizing ROS. H. sabdariffa is a type of herbal medicine. It contains polyphenol, antosianin, and flavonoid. Objective: The aim of this study is to find out the effect of H. sabdariffa on preventing the motor coordination disturbance due to ethanol. Method: Fourty male Wistar rats aged 21 day are divided randomly into 5 groups. Group A was given Nacl 0,9% (ip) and water (per oral). Group B was given ethanol 3g/kgbw (ip) and water (per oral). Group C was given ethanol 3g/kgbw (ip) and H. sabdariffa 0,75g/kgbw (per oral). Group D was given ethanol 3g/kgbw (ip) and H. sabdariffa 1,5 g/kgbw (per oral). Group E was given ethanol 3g/kgbw (ip) and H. sabdariffa 3g/kgbw (per oral). All groups were fed with antioxidants free rat food. All rats were treated for two days, every two days, for two weeks. Examination on motor coordination using revolving drum was conducted prior and subsequent to treatment. Results: The percentages of the differences of the transformed data of the number of falls in the revolving drum test from the highest to the lowest are as follows: 1,97% (the group A), 0,65% (the group B), 0,61% (the group C), 0,19% (the group D), 0,10% (the group E). The paired uji t of the number of falls demonstrates a significant difference between pre and post treatment in the ethanol group only (p<0,05). On the other hand the paired uji ts of the other groups show no significant differences (p>0,05). This means ethanol disrupts motor coordination ability in rats, and H. sabdariffa prevents the ethanol induced motor coordination disturbance. Conclusion: H. sabdariffa may prevent motor coordination disturbance and the ethanol disrupts motor coordination ability in rats.