Kewaspadaan standar merupakan sarana yang efektif untuk melindungi pasien dan petugas kesehatan dalam mengendalikan dan mencegah infeksiStandard Precautions are an effective means to protect patients and healthcare workers in controlling and preventing infection. The Health Belief Model (HBM) is a model predicting individual preventive health behavior Kepatuhan terhadap suatu standar merupakan perilaku yang dipengaruhi oleh faktor-faktor yang bisa dijelaskan dengan model HBM. Menurut model tersebut, perilaku dipengaruhi oleh : persepsi terhadap manfaat, persepsi terhadap hambatan, persepsi terhadap keparahan, persepsi terhadap kerentanan dan isyarat tindakan. According to the model, behavior is influenced by: the perceives benefits, perceives barriers, perceives severity, perceives susceptability and cues to action. The purpose of this study examines predictors of the factor most related to the compliance of nurses in the application of standard precautions in the Emergency Room and Intensive Care Unit Ciamis and Tasikmalaya Hospitals. Jenis penelitian yang digunakan adalah analitik korelasi dengan rancangan Cross Sectional .This type of analytic study is a correlation with Cross Sectional design. Subjek penelitian adalah 80 perawat yang bekerja di ruang IGD dan ICU RSUD Ciamis dan Tasikmalaya. Population subjects were 103 nurses working in the Emergency Room and Intensive Care Unit Ciamis and Tasikmalaya Hospitals. Based on rule of thumb, research subjects were 80 nurses working in the Emergency Room and Intensive Care Unit Ciamis and Tasikmalaya Hospitals. Data dikumpulkan menggunakan kuesioner yang diisi oleh responden. Data were collected using questionnaires filled out by respondents. Data dianalisis menggunakan korelasi Pearson Product Moment dilanjutkan dengan uji multivariat dengan analisis regresi linier. Variabel yang memiliki p value < 0,05 dapat diartikan bahwa variabel tersebut memiliki hubungan dengan variabel dependennya. Data were analyzed using Pearson Product Moment correlation test followed by multivariate linear regression analysis. Variables that have a p value <0.05 means that the variable has a relationship with the dependent variable. Jika uji asumsi normalitas, homoscedascity dan uji multicollinearity terpenuhi, maka model dapat digunakan untuk memprediksi variabel kewaspadaan standar. If test assumptions of normality, multicollinearity homoscedascity and test are met, then the model can be used to predict the variable standard precautions. Hasil penelitian menunjukkan variabel persepsi terhadap manfaat (p value 0,004) dan kerentanan (p value 0,000) mempengaruhi variabel kewaspadaan standar The results showed a variable perceived benefit (r = 0,472, p value 0.004) and perceives susceptibility (r = 0,482, p value 0.000) affect the variable standard precautions. Nilai β terbesar yaitu 0,379 pada variabel persepsi terhadap kerentanan, sehingga variabel tersebut dominan mempengaruhi perawat dalam penerapan kewaspadaan standar, baik cuci tangan atau penerapan sarung tangan. Largest β value of 0.379 to the perceives susceptibility variable, so that the dominant variable affecting nurses in the application of standard precautions, both hand washing or application of wearing gloves. Perceived susceptibility is most influences nurse's standard precautions.