The existence of Footwear Crafts Business Centers in Regency has the ability to survive and develop their business passed down from generation to generation. One effort to empower it is the promotion using e-commerce. However, E-Commerce is used by a few craftsmens. The objectives of this study is to analyze the factors that influence the adoption of e-commerce by SMEs. The results of this study indicate that (a) the compatibility and readiness of the organization variables are simultaneously able to explain the constructs of the perceived benefits by 58%, (b) Compatibility has a positive and significant impact on the perceived benefits, (c) Readiness Organizations have positive relationships and affect not significantly to the perceived benefits. Keywords: E-Commerce, Small Business, Entrepreneurship.