Typhonium flagelliforme (Lodd.) known as a medicinal plant to cure generative disease such as cancer. This research is focusing on isolation of endophytes bacteria from Typhonium flagelliforme (Lodd.). Twenty six of endophytes bacteria have been successfully isolated. Results indicated that nine isolates of bacteria could inhibit the growth of Bacillus subtilis and three isolates could inhibit Staphylococus aureus. The strongest secretion showed by KTD4 was 3.029 for Bacillus subtilis and KTBt1 2.042 for Staphylococcus aureus. Antioxidant activity tests of four selected isolates showed that KTBt4 could produce highest inhibition percentage up to 74.68% and IC50 68.103 ppm compared to vitamin C which is just 3.053 ppm.