Histopathology of the Telencephalon and Diencephalon of T1lapia Nilotica Exposed to Sublethal Dose of Malathion S-[1,2-di-(ethoxycarbonyl Ethyl) Dimethyl Phosphorothiolothionate]

Edna A. Amparado
Journal article Biotropia • 1992


A 35-day exposure of Tilapia nilotica embryos to sublethal doses of 3.0 ppm and 0.3 ppm malathion, S-[l,2-di-(ethoxycarbonyl ethyl) dimethyl phosphorothiolothionate], commercial grade, EC 57, produces cellular and ultrastructure changes in the brain. A number of nuclear centers of the treated animals are markedly larger than those of the control. Aberrant features observed in day-45 embryos are the neoplastic masses and increased vascularization. Ultrastructure defects include the presence of nuclear blebs, cytoplasmic vacuolations and increased lysosomal bodies.


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