L. This study was aimed to determine the ability of katuk that can affected cholesterol, glucose, erythrocyte, leukocyte, and thrombocyte during 3 weeks treatment. Twenty four does were raised from 6–12 month old, divided into three blocks, four treatment diets, and two replications. The treatments were P0= control diet, P1= 99% control diet + 1% katuk leaf meal, P2= 98% control diet + 2% katuk leaf meal, and P3= 97% control diet + 3% katuk leaf meal. The variables observed were cholesterol, glucose, erythrocyte, leukocyte, and thrombocyte. Cholesterol and glucode were determined with colorimetri methode with GOD-PAP, erythrocyte, leukocyte, and trombocyte with haemocytometer. Data were analyzed using analysis of variance (anova), followed by Duncan's Multiple Test Range. The results showed that addition of katuk leaf meal can decreased cholesterol (50.67–48.34 mg/dl) and glucose (119–115 mg/dl) and increased erythrocyte (6.17–6.25x106/mm3) during 3 weeks experiment, whereas leukocyte, and thrombocyte not affected by katuk leaf meal. It is concluded that addition katuk leaf meal can decreased cholesterol and glucose and increased erythrocyte, whereas leukocyte and thrombocyte not affected by katuk leaf meal.