Background: The hospitalization and mortality rate for gastroduodenal ulcer in the elderly remain very high. It may be attributed to increase prescriptions for gastroduodenal damaging drugs, including the non-steroidal anti inflammatory drugs (NSAIDs). The aim of this study was to determine the profile of elderly patients' characteristics who had undergone esophagogastroduodenoscopy (EGD) at Kariadi Hospital. Method: A cross sectional study was conducted in elderly patients with non-variceal EGD at Kariadi Hospital, Semarang between Januari 2009 and December 2010. Analysis statistic was performed using chi-square test, with SPSS version 19. Results: Among records for a total of 164 cases of eldery patients who had undergone EGD, 90 patients were enrolled in this study. There were 64 (71.1%) male patients and the most chief complaint was hematemesis (22.2%). The most common indication for EGD was upper gastrointestinal tract bleeding (55.6%). EGD results demonstrated that the most common finding was mild abnormalities (56.7%). Gastric ulcer was found in EGD results in 38.0% cases with upper gastrointestinal bleeding (PR = 5.5; 95% CI = 1.7-17.9; p = 0.002). Moreover, the gastric ulcer was also found in 42.3% among NSAIDs users (PR = 3.2; 95% CI = 1.2-8.6). Conclusion: Upper gastrointestinal tract bleeding is the most common indication for EGD in elderly patients at Kariadi Hospital, Semarang. The most EGD image was only mild abnormalities followed by gastric ulcer. In the study, upper gastrointestinal bleeding is associated with high incidence of gastric ulcer, which also correlated with high incidence of NSAIDs utilization.