The diptheria cases raised up in Bangkalan District in 2015, as many as 19 case with CFR 15,79% spread in 13 subdistricts/villages. This study was to analyze the risk factors the corelated factors to dipheria cases of children with case control design and analyses data using computer computing. It condusted in July-December 2016 by using questionnaire, interviews, observation, and measurement. Total sample was 48 respondents which number of case 8 respondents and number of control 40 respondents. Variabel in this study were characteristic (age, sex, level of education), the completeness of immunization DPT, and the condition of the physical environment of the house. Characteristic (level of education), the completeness of immunization DPT, and the condition of the physical environment of the house had corelated to diptheria cases. The most influential variable was the completeness of immunization DPT (p value = 0,037; OR = 4,667). Health workers in particular in collaboration with the village midwife cadres need to increase it's role as educator and conselor in providing information in the form of outreach to the community related to the risk of transmission of diphtheria and immunization basics awarding benefits to the entire Neighborhood/village at Posyandu activities until it reaches the target UCI.