. Leprosy is a general health problem because can be causes of disability. Routine Self-care is needed prevent existing defects. This study is aim to describe self-care of leprosy patients in work area of Bendan and Jenggot Primary Health Care Pekalongan City, 2015. This study used descriptive study. Populations in this study were all of leprosy patients in work area of Bendan and Jenggot Primary Health Care about 42 patients. To select certain participant used total sampling technique. Result of this study showed 19 (52.8%) do not perform self-care and 17 (47.2%) perform self-care. Self-care is an act to maintain cleanliness and health of a personal's well-being, both of physical and psychological. Interest in self-care is no more affected than the desire itself and did not need any help from the family. They believe when self-care is done regularly will reduce the risk of a more severe disability. More families are expected to motivate lepers to always perform self-care by providing information about leprosy in particular on self-care.