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Bromelain as an Anti-inflammatory and Anti-cancer Compound

Inflammation is a complicated problem for today's human beings. Large numbers of people have been diagnosed with arthritis along with inflammation. This is beside the others that suffer inflammation caused by an injury. There are alternatives that can be considered as temporary or permanent treatments of chronic inflammatory diseases. Plants, as well as other biological resources, are most welcomed to the therapeutic area. Using the plants' compounds with high potential as novel techniques are today's bio-pharmacologist concern. Bromelain has been more attractive due to its characteristics. This review is an overview of anti-inflammatory and anti-cancer effect of bromelain as a confident treatment for all inflammatory disease.
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Anthelmintic Activity of Leaves Extracts of Olea Europaea on Pheretima Posthuma

Parasitic roundworms (nematodes) cause substantial morbidity and mortality in livestock animals globally and considerable productivity losses to farmers. The control of these nematodes has relied largely on the use of a limited number of anthelmintics. However, resistance to many of these anthelmintics is now widespread, and, therefore, there is a need to find new drugs to ensure sustained and effective treatment and control into the future. The present study was undertaken to evaluate the anthelmintic activity of crude aqueous, Petroleum ether, chloroform and methanol extract Olea europaea leaves using Pheretima posthuma as test worms. Single concentration (5%) of extracts was tested in the bioassay, which involved the determination of the time of paralysis (P) and time of death (D) of the worms. Piperazine citrate was included as a standard reference and distilled water as a control. The results of the present study indicated that Olea europaea leaves extracts were exhibited anthelmintic activity significantly when compared with the standard (Piperazine citrate) group. Further studies are in process to isolate the active principles responsible for the activity.
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Preclinical Toxicological Evaluation of Aloe Vera Health Drinks in Wistar Rats

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Formulation and Invitro Evaluation of Oral Extended Release Microspheres of Aceclofenac Using Various Natural Polymers

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Osmotic Drug Delivery System of Valsartan

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Preclinical Toxicological Evaluation of Aloe Vera Health Drinks in Wistar Rats

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Formulation and Invitro Evaluation of Oral Extended Release Microspheres of Aceclofenac Using Various Natural Polymers

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Osmotic Drug Delivery System of Valsartan

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Formulation and Evaluation of Fast Disintegrating Tablets of Metoprolol Succinate Using Various Superdisintegrants

The aim of present work is to develop a Fast disintegrating solid oral dosage form of Metoprolol succinate. The concept of Fast dissolving drug delivery system emerged from the desire to provide patient with more conventional means of taking their medication. Problems associated with conventional tablets can be resolved by means of Fast dissolving tablets when put on tongue these tablets disintegrate and dissolve rapidly in saliva without need of drinking water. The Faster the drug disintegrates in to solution, the quicker the absorption and onset of clinical effect. Preformulation results reveal that the flow properties of the active pharmaceutical ingredient were found to be excellent as per IP limits. To perform drug-polymer compatibility FT-IR studies were carried out and observed that there was no interaction between the APl and excipients. Eight formulations were prepared with varying super disintegrating agent ratios and were found that as the level of super disintegrating agent decreased the drug release rates were found to be increased. Amongst all the formulations, formulation containing CCS (F4) as super disintegrant is fulfilling all the parameters satisfactorily. It has shown excellent in-vitro disintegration, in-vitro dissolution compared to other formulations. The prepared tablets disintegrate within few minutes without need of water; thereby enhance the absorption leading to its increased bioavailability. It was concluded that Fast Disintegrating tablets of Metoprolol can be prepared successfully as it satisfies all the criteria as a dispersible tablet and would be alternative to the currently available conventional tablets. Prepared formulations were stable during 90 days storage period at controlled 40°C and 75%RH.
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Assessment of In-Vitro Cytotoxicity and In-Vivo Antitumor Activity of Syzygium Aqueum

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