The purpose of our work was to analyze the functional state of the hemostasis system in traumatic illness in patients with increased body mass index, polytrauma, systemic multivariate analysis. (IВMІ). A comprehensive hemostatic study was conducted in 224 patients with IВMІ during the month of stay in a hospital with a diagnosis of "polytrauma" and on the 360th day of an outpatient visit, which included the study of indicators of cellular, plasma units of hemostasis and fibrinolysis. We conducted a systematic multifactorial analysis of the obtained results, which allowed integrating the mathematical model to assess the overall state of the platelet system, coagulation hemostasis and fibrinolysis in patients with IВMІ polytrauma. The general laws of their response to a traumatic illness were determined as well as features that are characteristic for each of the examined groups of patients.