Introduction: The relation between self care and patient's diabetes mellitus quality of life in Persatuan Diabetes Indonesia (PERSADIA) in Cimahi. Self care ability is important in improving patient's quality of life (QOL). Method: Using cross sectional method, this research is designed to identify the relationship between self care and patient's QOL in PERSADIA Cimahi, West Java. A hundred twenty five PERSADIA members were recruited and examined using Summary of Diabetes Self-Care Activities (SDSCA),Diabetes Quality Of Life (DQOL) and Beck Depression Inventory II. Result: The results showed no significant correlation between self care activity and QOL (p=0,164) as influenced by gender (p=0,006), depression (p=0,001). Discussion: Increase of one unit self-care was likely to increase 6,1% QOL after controlled by gender and depression. Self care improvement can be performed through developing structured education, improving nurse's competency in diabetes care and conducting diabetes screening program for DM patients.