Women in small enterprises faced not only general obstacles faced by marginal and informal economic sectors. They also faced problem arose from gender stereotype. Those problems have put women's business in high-risk situation and vulnerable. Since women's contribute is significant in the national economy, it is important to put efforts to solve women small-entrepreneur problem. This article proposed the systematic way of understanding women small-entrepreneurs' vulnerability and effective empowerment and organizing activity. The first section of this article discussed conceptual framework in understanding the vulnerability concept in women small-entrepreneur. The second section discussed several relevant questions to conduct field research. The last section discussed the implication of this approach in empowering and organizing women.