: We have developed a virtual laboratory for teaching modern physics. The purpose of this study is to examine the effectiveness of a virtual laboratory model of modern physics on students' generic science skills. The study involved 64 students who were divided into two groups, the experimental group and control group. The research instrument used a generic science skills test that is integrated with the mastery of concepts of modern physics. Data were analyzed by using mean-difference test and normalized gain scores. The results showed an increase in generic science skills in both groups. Indicators showed that the highest increases are logical inference capability and the ability to build concepts. These results indicate that the virtual laboratory model of modern physics is effective in enhancing generic science skills of students.