Background: Indonesia is an archipelago. Most of Indonesian's population live in coastal areas as smoked fish makers. Negative impacts of continuous smoke exposure directly on oral cavity can lead to pathological conditions such as caries. The content of the smoke which is suspected to cause dental caries is tar and acid compounds.Aims: To investigate the relationship between smoke exposure with the occurence of dental caries in the curing fish labor in Bandarharjo village, Semarang RegencyMethods: This type of research is conducted with a cross-sectional design. Samples were taken using a non-probability sampling technique with consecutive sampling type, normality test by using the Shapiro Wilk and bivariate hypotheses analysis test with the Chi-Square test and Independen t-test.Results: There were significant caries differences in groups exposed and not exposed to smoke (p <0.05).Conclusion: There is a significant association between smoke exposure with the occurence of dental caries in curing fish workers in the Bandarharjo village, Semarang Regency, Central Java.