Medication errors are a very serious problem in health care services around the world. These problems lead to morbidity and mortality for patients, as well as increase the costs to be incurred by the hospital. Medication errors may occur at any stages of medication management and use process and result in patient safety. These may occur due to latent conditions, error producing conditions, and active failures. Nurses who are primarily involved in the process of medication administration have important role in preventing, recognizing, and addressing errors in order to enhance safety medication administration. Efforts to enhance safety medication administration may be done through nursing process approach from assessment to evaluation and documentation.