The effect of continuous professional development to the implementation of pain managment by nurses in hospital. Continuing Professional Development (CPD) is a component of a career ladder system which its planning and implementation can affect in a nurse's life process. In some hospitals, the nursing career ladder system were not associated with recruitment, rotation, continuous professional development and promotion process. This study aimed to identify the effect of CPD to the implementation of pain management in a hospital. The design research was descriptive correlative with cross sectional approach. Data were collected through primary data as much as 121 nurses and also secondary data from patient medical records related to pain management nursing documentation included assessment, intervention, and re-evaluation. The sampling technique was simple random sampling. Data were analyzed by multiple linear regression. The result showed that the variables of the career ladder system implementation that most affected on the pain management implementation by clinical nurses is continuing professional development (CPD)(p= 0.027). It is recommended to make structured planning through training needs analysis for each nurse.