This study aims to explain the relationship between therapeutic communication done by nurses and the anxiety of family members of hospitalized child who are suffering from infectious diseases. A total of 44 respondents were included in this study using purposive sampling technique. The data were taken using a questionnaire on therapeutic communication and anxiety with a closed question types. The data then were processed using Kendal tau statistical tests with 95% significance level. The results of the analysis shows that 75 % of respondents experienced minor anxiety, 13.6 % had moderate anxiety, and 11.4 % had severe anxiety. Data on therapeutic communication indicates that 9.1 % of nurses less communicate, 52.3 % make enough communication, and 36.6 % make a good communication. Correlation analysis using Kendal tau technique shows that there is a relationship between therapeutic communication done by a nurse and the degree of anxiety experienced by families whose child are being hospitalized with infectious diseases (ä = -0.34 , p = 0.018 ). Nurses should always apply the principles of therapeutic communication to communicate with patients because it can minimize the stress and improve the process of adaptation to stress.