Effect of particle nano on antiageing activities of cream had performed. In this research, the antiageing activities for common cream and particle nano cream have tested using experimental animal. Common cream with particle size 1439.8 nm-2573.4 nm was prepared by convensional methode, the other hand particle nano cream (54.6-91.8 nm) was prepared by ultrasonication. Futhermore, market cream with particle size is 548.2-975 nm then ultrasonicated be 72.4-132.2 nm. Antiageing testing result of particle nano cream shows score wrinkles is zero. From this result, particle nano cream has potential to protect of skin damage. Moreover, the testing result of antiageing activities of market cream have been increasing from 0.25 wrinkles to be 0 wrinkles after reprocess to be particle nano by ultrasonicated.