Introduction: Uric acid is the last product of purin metabolism. The amount of uric acid in blood influenced by food high purines and or impairement of uric acid excretion in kidney. Acupressure is one of nursing intervention by giving a pressure on specific point. There was many research about acupressure effectivity, but none did research about the effect of acupressure therapy on blood uric acid level. Objective: This study aimed to find out the effect of acupressure therapy on blood uric acid level towads elderly at Panti Wreda Catur Nugraha Kabupaten Banyumas. Method: This study used pre experiment design with pre test- post test without control approach design and total sampling technique. The amount of sample was 11 respondent which had fulfill the inclution and exclution criteria. Data analysis used by statistical paired t test. Result: The average of uric acid level before accupressure therapy was 5.99 mg/dl and uric acid level after acupressure therapy was 4.04 mg/dl. The result of paired t test was obtained t= 2.441 (obtained t > table t) and value of p=0.035 (p<α=0,05). Discussion: The decrease of average blood uric acid level occured by kidney improvement in uric acid secretion and reduction of purin from muscle glicolisis as a consequence of stress. There was a significant effect of acupressure therapy on blood uric acid level in elderly at Panti Werdha Catur Nugraha Kabupaten Banyumas. Acupressure therapy could decrease blood uric acid level on elderly at Panti Wreda Catur Nugraha Kabupaten Banyumas.