Introduction: Without health management, hypercholesterolemic clients would have cardiovascular diseases as complication, and even death. Exercise and anti-hyperlipidemic medication can decreased these health risks Lime (Citrus aurantifolia) possess phytochemicals that have reducing effects on blood cholesterol. Aim: To determine the effects of lime (Citrus aurantifolia) therapy and lime therapy with exercise on reducing blood total cholesterol level. Method: This study utilized a quasi-experimental design which compared two groups intervention. A purposive sampling technique was used to select 20 participants that randomly divided into 2 intervention groups. Participants in the first group drinks 1,5 cc/kgbw of lime juice every morning for 7 days. While participants in the second group drinks the same dosage of lime juice with 30 minutes exercise every day for 6 days. Results: The mean of total cholesterol level of participants in both groups before and after intervention reveal a significant changes (p=<.05). While the gain score of the two groups reveals no significant difference. Discussion: Lime juice therapy effective in reducing blood total cholesterol level for its active phytochemicals that acts as hypolipidemic agent.