PT. Mondrian is a company that specializes in manufacturing that produce garment products include Sekido, Begaya and Dadung. To distribute their products, PT. Mondrian divide into four regional marketing. In this research the distribution is limited to distribution centers in Klaten district, while the goal in the region of Central Java and Yogyakarta Special Region. The important decision operational in supply chain is determination of product delivery routes from the central warehouse to multiple destinations, thus obtained can optimize the route of transportation costs. Therefore needed a method that can help determine an effective delivery route of saving matrix method and generalized assignment method. Saving matrix method works by creating a matrix called the matrix of savings or saving matrix, this matrix contains a list of savings obtained if the combined demand of two retailers in a vehicle with a vehicle capacity while considering the generalized assignment method works by determining Seed Point or the midpoint of the vehicle and then calculate insertion distance for each retailer. From the results obtained that the data processing method of saving matrix provides an effective.