Approximately 10–30% of adult Asian people had metabolic syndrome. This study aimed to reveal effects of workplace health promotion (WHP) with multilevel interventions on workers' metabolic syndrome component. This study was conducted in 2014-2015 using quasi-experimental design with multilevel subject intervention in Indonesia. The WHP program for multilevel intervention group included 12 weeks of combined physical training, diet, health education, social support, and advocacy. The WHP program for control group included only health education. Instruments used included IPAQ, table of 24-hour food recall, physical measurement tools, and clinical laboratories. Data analysis used Marginal Homogeneity, paired sample t-test, Mc Nemar, and Wilcoxon test. WHP multilevel intervention could improve physical activity and the nutrition in accordance with diet of workers, in particular to increase the amount of fiber and a reduce cholesterol intake. The improved metabolic syndrome components due to the influence of multilevel WHP were systolic and diastolic blood pressure, and fasting blood glucose levels (p value < 0.05). Overall, workplace health promotion multilevel interventions are effective for the management of metabolic syndrome components.