Peripheral Arterial Occlusive Disease (PAOD) is defined as a disease results either from atherosclerotic or inflammatory processes causing lumen narrowing (stenosis), or from thrombus formation so there is an increase in vessel resistance that can lead to a reduction in distal perfusion pressure and blood flow. PAOD especially suffers the lower extremities has a high morbidity rate because its etiology, pathophysiology, clinical signs, diagnosis, complications, prevention, and management are still not well defined. Because of the variety of clinical signs, misdiagnostic, and complications assosiated with PAOD, it is important to increase the diagnostic accuracy obtained mainly by anamnesis, physical findings, and supporting laboratory studies. An early management and a better perioperative care must be done to treat PAOD complications resulted either from its disease or reconstruction artery operative. Hopefully, a better clinical understanding and a better management toward PAOD patients will lead to a better prognostic outcome, especially to those patients that shows the signs of risk factors toward PAOD such as smokers, diabetic and hypertension patients, and genetic abnormalities. Therefore, it is important to enhance the know of the PAOD particularily in the term of its diagnostic criteria, prevention, and management. This awareness and activity not only for doctors and medical students, but also for the community, by means of symposia, discussion forums, or other else.