Orally Disintegrating Tablet (ODT) or Fast Release Tablet is solid dosage form whichdisintegrated rapidly in mouth and its residue easy to swallowed. This research observedthe influence of Ac-Di-Sol concentration as disintegrant on physical characteristicsand dissolution rate of piroxicam orally disintegrating tablet which wereprepared by direct compression. Ac-Di-Sol was used in concentration of 1%, 3% and5%, and 0% as control. The powder blend was pressed into tablet by hydraulic presswith a pressure of 1 ton and diameter of 8 mm and its hardness, friability, disintegrationtime and dissolution rate were examined. The results showed that the increasingof Ac-Di-Sol concentration would increase hardness, disintegration time, dissolutionrate and decrease friability of the tablet. From statistical analysis (µ =0,05), it wasshowed that there was significant difference among formulas on the hardness, friability,disintegration time and dissolution rate. The hardness of piroxicam Orally DisintegratingTablet of all formulas were between 0.99 - 2.77 kP, friability were between3.45 – 1.35%, disintegration time were between 223.67 – 20,0 sec and drug releasedat 45 minutes were between 32.71 – 96.25%. From this research, it could be concludedthat formula with 3% concentration of Ac- Di-Sol give the most desirableoutput, even though there was a problem with the friability.