Study on the potential combination of Asystasia gangetica ssp. micrantha and Apium graveolens L. tea for anti diabetes mellitus and its effective dose has been conducted on male Mus musculus. Complete random design with 5 treatments: positive and negative controls, 31,43 mg/30 g body weight (bw), 54.60 mg/30 g bw, 62.86 g/30 g bw with 4 replications was applied. Data was analyzed using ANOVA and LSD at 5%. After seven days infusion treatments indicated that there was significantly decrease in blood glucose level. The highest dose of 62.86 mg/30 g decreased mice's blood glucose level closed to their normal level.