Development policy that is based on regional characteristics (endogenous development) through local resources potency optimization is a requirement to achieve the goal of regional economy development. Identification of potential economic sectors is an effort to accelerate achieving process of economy development. This research aims to determine economic structure and dominant sector in district of Mesuji. This research use secondary data of time series data of Gross Domestic Regional of Mesuji and Lampung in 2010-2012. Analysis tool that is used is Typology Klassen, Location Quotient, and Shift-Share. Result of Typology Klassen show that advance and rapidly growing sector is trading, hotel, and restaurant. Result of Location Quotient show that base sector in Mesuji is agriculture, industry, trading, hotel, and restaurant. Result of shift-share analysis show that compatible sector is agriculture, industry, trading, hotel and restaurant. Result of analysis per sector based on three analysis show that dominant sector of economy in Mesuji that advance and rapidly growing, base sector, and competitive are trading sector, hotel sector, and restaurant sector.