This study investigated the effect of EGCG from GMB4 green tea clones inhibit increasing cholesterol levels in male rats with high fat diet. Wistar male rats were fed a diet high inÂ fat for 2 months from 8 weeks of age and determination of the object of research with completely randomized designÂ five treatments and EGCG was given by sonde. Blood cholesterol levels by spektrophometry. EGCG treatment decreasedÂ cholesterol levels (p<0.05). Cholesterol levels decreased 55%(p=0.00) at doses of 8 mg / BW. The Results suggested that EGCG one of the most abundant catechins contained in green tea effectively inhibits increased cholesterol levels, that risk factor for cardio vascular disease.