Use the right brain needs to be optimized for a variety of human interests, among them for the benefit of running a business. This is because of in addition to using the left brain to think on things that are a matter of mathematics and economics of running a business, the right brain is also necessary for the creation of the things that are strategic to the business. This study was a qualitative study based on a study of students who have received support Program Mahasiswa Wirausaha/PMW (Entrepreneur Student Program) at the Madura Trunojoyo University. The population was all students who have received funding from several years ago while samples taken at random purposive sampling is directed toward students who have successfully become entrepreneurs based onÂ Depdikbud(Nas) criteria. The purpose of this study was to describe the respondents' experience in running a successful business by optimizing the use of the right brain. Based on the results of the study found that they essentially become an entrepreneur's success is inseparable from optimizing the use of the right brain. According to them that in running a business and to compete with other businesses can not rely solely on capital (funds), but also be able to create a competitive strategy. Creation of competitive strategies derived from optimizing the use of the right brain, such as the creation of the differentiation strategy. Differentiation strategies they need to be done by making a different product or service and with a product or service created by the competitors.