Neuropathy is one of the most common complications in patients with diabetes mellitus (DM). Neuropathy has contributed to some impacts of quality of life (QOL), general health status, and socio-economy level. Therefore, it is important to understand more about this issue, so appropriate treatment could be taken to improve QOL of patients with diabetic neuropathy. This study aimed to measure the profile of a patient's life quality in DM with neuropathy. This study was a observational study using Short Form 8 (SF-8) Health Survey Standard Indonesia to measure the QOL in patients with diabetic neuropathy that were treated consecutively from March to August 2016 in the Department of Neurology in Bethesda Hospital, Yogyakarta. Fifty seven patients with diabetic neuropathy were enrolled as subjects in this study. Most of them were women (52,6%). The mean age of subjects was 57.3 ± 5.85 years. The lowest QOL score in patients with diabetic neuropathy were observed in general health perceptions category (45.26%), followed by bodily pain (57.19%), vitality or energy (69.12%), physical functioning (69.82%), social role functioning (74.03%), mental health (78.59%), physical role functioning (80.70%), and emotional role functioning (81.05%). Patients with diabetic neuropathy have poor QOL. Sex and age were not significantly related to the QOL in patients with diabetic neuropathy.