One of the SMEs exists in Central Java is Batik Industry. Batik is a traditional Indonesian art in the form of patterned fabric which has existed since centuries ago, lives and thrive in almost every district and town across Central Java, including Banyumas batik which has a unique characteristics. From 2012 to 2014, there is a decline in the number of sales in Banyumas batik. A decrease in the number of sales is caused by Banyumas batik SMEs takes a long time to sold. Therefore it is very necessary to have a business strategy that fits Banyumas batik SMEs. The aim of this study is to develop a business strategy in SWOT, using SPACE matrix and QSPM matrix, also formulate business strategies in accordance with the Banyumas batik SMEs. There are nine alternative strategies, by using QSPM matrix, the chosen strategic priorities are batik SMEs create brochures, leafllet and through social media so that people know the existence of Banyumas batik SMEs, so that the possibility of an increase in the volume of sales by the largest TAS value of 5.98, offering products to various agencies of other organizations that have never ordered Banyumas batik to expand the partnership network has the largest TAS 5.70 and cooperated with the government in order to be built the central market concentration point of sales and production centers and overall strategic location has the largest TAS 5.04.