A diagnosis of breast cancer raises a meaningful stress and can get depressed. By knowing the emotional state of breast cancer patients who experience symptoms of depression after being diagnosed, treatment can be done in a comprehensive manner with the hope of treatment can be wor optimally. The purpose of this research is to know the relationship of depression symptoms with breast cancer stage in POSA RSDS. Type of research is observational analytic on breast cancer patients first visit POSA RSDS June-July 2016. This research use questionnaire BDI-II to measure the subject's sympto ms of depression. Analytical test used is the Spearman Correlation. Results, obtained 43 subjects entirely women with most age range 45-59 years (60.5%), educational history most high school(41.9%), and most work as housewives (74.4%). 46.5% dominated by stage III, and 62.8% BDI-II results with no symptoms of depression. Analytical test indicates a weak relationship (Sig. 0.009 < 0.396, rs = 0.05). A weak relationship between variables because distribution of uneven stage; the majority of the BDI-II showed no symptoms of depression, acceptance phasebetween subjects against the conditions of his illness, researchers estimate the condition of the spirituality subject is good and can affect the subject's emotional condition conducive for researchers. Spirituality subject of research is good to make the subject of the research arose from slump, and the subject of more religious, positive support from family, positive support from fellow cancer survivors who have been healed. Conclusion, there is a relationship between depression symptoms with the staging of breast cancer.