Penelitian Toksisitas Daun Stevia Rebaudiana Bertonii M Pada Mencit Dan Tikus Putih

B. Wahjoedi • Hutapea J. • Iwan T. Budiarso
Journal article Indonesian Bulletin of Health Research • March 1985 Indonesia

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The acute and subchronic toxicity tests were carried out on the aquaous extract of the leaves of Stevia rebaudiana Bertonii M. obtained from the Balai Penelitian Tanaman Obat in Tawamangu, Surakarta, Central Java. The acute toxicity test was done by the Weil's method (1952) on mice and the subchronic toxicity test was done on rats by a method developed by the Pharmaceutical Research and DeveĀ­lopment Center of the National Institute of Health Research and Development, Jakarta. The results are : the leaves of Stevia rebaudiana Bertonii M. can be grouped into substances which are "practically non-toxic" based on the criteria used by Gleason (1969) and the oral administration of doses up to 320 mg/100 g body weight daily for 6 months showed no negative effect on the organs of the animals examined.




Indonesian Bulletin of Health Research

Buletin Penelitian Kesehatan (Indonesian Bulletin of Health Research) is a quarterly, open access... see more