Brotowali (Tinospora tuberculata Beaumae), Meniran (Phyllanthus niruri L.). Bengle (Zingiber cas-sumunar Roxb.) and Tapak limau (Elephantopus scaber L.) are four plants that have been known to have antipyretic property. To confirm the antipyretic property, materials obtained from The Balai Penelitian Tanaman Obat Tawangmangu, Surakarta (Central Java) were tested on fever induced rats. The fever depressing effect of 750 mg symplicium/100 g body weight on ratsdid not differ significantly that of 30 mg sodium salicylate/100g body weight. No dosage-response relationship was seen in the four symplicia, and thterefore it is not advisable to recommend the use of those symplicia as antipyretis.