Background: Empowerment program aims at improving the independency in social economic sector or psychology. Theresearch aims at formulating the development of empowerment program to improve the independency of the housewiveswith HIV. Method: The research is a qualitative and its design is an exploration research. The subjects of the researchare ten housewives with HIV, the members of Women Empowerment Community/WE Surabaya. Data collection uses indepth interview and Focus Group Discussion (FGD). Results: Research result shows that the subject character has noinfl uence on the kind of the desired empowerment program. The majority of problem lies on the aspect of social economyand the need for economic improvement. Innovation character which infl uences the adoption of empowerment programwhich is now WE developing is the relative advantage while social systems which effect is the friends who even prove tobe the agent of change. WE empowerment program has actually met the concept of empowerment program; it providesmembers with human resources, opportunity, knowledge as well as skill but it still unable to provide the result according tothe program goal. Recommendations: Government and NGO are expected to develop program according to the problem,need and the ability of the housewives with HIV in such a way that empowerment program improve their independencyparticularly in the sector of social economy.