Background: Cardiovascular disease was claimed as a leading cause of death in women > 65 years old in Europe. Coronary Heart Disease (CHD) was major cause of death in women in the USA, a half of million women dead because of cardiovascular disease every year. Riskesdas 2007 shows that prevalence of cardiovascular disease in women was higher than man based on diagnosis (1.0% versus 0.8%) or diagnosis and symptoms (8.1% versus 6.2%). The aim of this study was to explore determinants risk factors of CHD in women (sociodemography, behavior risk factors, and blood examination). Methods: Cross sectional with in depth analysis The sample took from sub set data of cohort study of non-communicable disease in sub district Kebon Kalapa, Central Bogor in Bogor City by Center of Intervention Technology of Public Health. Dependent variable was CHD in women with independent variables were socio demography factors, behavior risk factors, and biomedical risk factors. Samples were 1042 respondents, women who had CHD. The criteria of CHD based on examination of ECG with abnormal results. Data analysis conducted by Chi square and logistic regression. Result: The result of this study shows that determinant factors of CHD in women were menopause OR = 1.5 (95% CI 1.2152.081); waist circumstances OR = 1.5 (95% CI 1.1472.221); and triglyceride level OR = 1 (95% CI 1.0101.253). Conclusion: The women with menopause and central obesity had high risk on CHD. Recommendation: Health promotion should have done to decrease CHD prevalence.