Background: Malaria remains health problem that not decrease it rate yet. Outcome that clearly follows malaria is disability that made 60 thousand Dollars lost from Indonesian people who live in endemic areas due to this disease. This article need to analyzed Riskesdas data to define malaria influences to disability, what malaria that impact larger to disability, outcome disability caused by malaria could make patient's productive day lost and socio-economic loss and to find out the differences of malaria burden between western and eastern Indonesia. Method: Analysis used Riskesdas data by cross sectional design. Scopes of analysis include malaria and disability data that confounded with other disease that may induce disability. Data analyzed with scoring according to WHODAS 2.0 and logistic regression, also people's economic loss consideration due to malaria that reduce productive day. Result: The result showed that malaria trigger disability 1,6 fold, and western Indonesia 1,2 fold more risky to disability. Malaria tropica (Plasmodium falciparum) and tertiana (P. vivax) did not significantly different to cause disability. Productive day loss, western Indonesia slightly larger than eastern Indonesia. Malaria could inflict a financial loss of the malaria suffere in the amount of Rp. 390.620.016 from one day loss of work due to malaria. Conclusion:There's a significant correlation between malaria and disability, however there was no significant difference of productive day loss between eastern and western Indonesia. Recommendation: Need for enhance effort to eliminate malaria, upgrade health and medical attendance for malaria patient, increase health service access for free particularly for poor community.