Background: Eradication of infectious diseases required information based on location which called geographic information system to make decision. One of re emerging disease was diphtheria. Diphtheria in East Java increased and became the biggest case. In 2010 were 73% and in 2011 became the first case in the world within 664 cases with CFR 2,6%. Objective: this study did to analyze diphtheria by spatial data which correlated with the risk factors in East Java in 2010–2011. Design of this research was un-obstrusive with secondary data from BPS statistic and health office of East Java. Population was thirteen eight Districs in East Java and it was taken for sample. Spasial data was analyzed by overlying between dependent variable and risk factors. Result of this study diphtheria tends increase in 2010–2011. There is domination of case in horseshoe region include Surabaya, Malang, Madura and the surrounding area. Result:result of overlay between diphtheria with risk factors show population density, sex, education, expendicture per capita, and the healthy house not always become the risk factors of diphtheria. DPT3 and DT immunization shows there is correlation between diphtheria and statistically have moderate power (r = 0,424 and r = 0,348). Conclusion: The factors immununization DPT3 and DT was support to became diptheria. Recommendation: The spatial data analysis for each sub-region shall be held due to special characteristics of subregion.