Background: Report on Result of National Basic Health Research (Riskesdas) 2007 by National Institute Health Research & Development Ministry of Health showed that only 38.7% prevalence Behavior of Clean and Healthy Living (PHBS). This means that most residents do not behave in a clean and healthy living. Promotion of clean and healthy lifestyle needs to start early age to become additional knowledge and further expected to be practiced in everyday life, and become part of norm of their lives. Method: This research is applied in the form of an experiment to test the Commumcation, Information and Education (KIE) technique designed in this study with aims to increase the children knowledge about PHBS and infectious disease. The first phase, the object of research is children who are chosen as samples are given a questionnaire to determine the extent of their understanding of clean and healthy lifestyle and infectious diseases. The second phase they received treatment in the form of the game e-games that are played for at least 2 times the time span for 2 weeks. The third stage they received the same questionnaire as in the first stage. Result: Based on the different test results showed that there was a significant increase between the average value of knowledge before and after treatment.