Background: Predicted in 2015 there was an increase of 924.000 cases with a prevalence of 0.49%, and rose sharply to 2.117 million cases in 2025 with a prevalence of 1.00%. This surge can be prevented to less than half that when the target of universal access can be achieved by 2014. For prevention, FJPA using Facebook as a medium of information delivery. This effort shows remarkable progress. This development becomes interesting to study, how the effectiveness of Facebook Social Media Networking in a process of diffusion of information related to HIV/AIDS. Methods: The method used in this analysis is content analysis. Observations conducted in 2010, March 18, 2010 until December 31, 2010. Result: The results showed a sharp increase in membership FJPA on Facebook that reach 2821 members by 2010. Membership has exceeded the limits of the country, including men and women almost equally, dominated age. FJPA page on Facebook last ten months has been accessed 4278 times, the interaction peak in the first month (March 2010) 430 interactions, and six months subsequent interaction 77-132 per month, and peaked back in December of 309. Posting an entry consisting of 126 wall posts, links 31, and 35 notes. It can be concluded that the Social Networking Media through the Internet very effectively as a medium of diffusion of information which transcends geographical and administrative regions. Social Networking is also an effective medium for dissemination of information to target youth and age. The recommendation is: Social Media Networks need more intensive process of diffusion health information, specially productive age as a target; The review also needs to be continued to look at the effectiveness of other social networking media. Such as Twiter, Koprol, Blogs, and so on.