A disaster is incident which can be avoided although it is naturally. But if it happenned, there are extra ordinary activities which should be managed as an emergency state. Disasters which happenned in Nangroe Aceh Darussalam, Nias and Alor is a lesson teamed process that in health mechanism of emergency response there are things that can be anticipated. Mobilization of sources included health personnels could be done by provinces, districts or municipalities which were nearest to the disaster areas. This mechanism is built with management and operational tasks which is clearly explained, what should be done in the emergency response. This is a case study which data were collected through interviews and secondary data. The respondents were purposively selected. Analysis was to answer the objectives of the study that is to develop a health mechanism prototype in disaster as lesson teamed on Nangroe Aceh Darussalam, Nias and Alor cases. The prototype of health mechanism in disaster was developed on lesson teamed from interviews and secondary data in Nangroe Aceh Darussalam, Nias and Alor. The prototype is developed with consideration on local specific disasters. The document of this prototype should be added with policies, including mapping and identification of local specific disasters. These all would be things that could be completed in preparedness, mitigation and prevention of disaster.