Extraction of chemical warfare agents (CWA's), O-ethyl S-2-(diisopropylamino)ethyl methylphosphonothiolate (VX) in soil sample has been done. The extraction was performed using six different solvents at ambient and cold temperature. Percent recovery of VX in soil samples was quantitatively determined by mean of LC-Tandem MS using selected reaction monitoring (SRM). The degradation products of the VX were screened by using multiple reactions monitoring (MRM). The storing effect investigation has shown the ability to extract the VX in soil samples and the application of LC-MS was most useful to detect the VX after cold water extraction, but not for its degradation products.