Data of Riskesdas 2016 shows increasing in some diseases (underweight, stunting, hypertension, TB, AIDS, etc.) compared to 2007 and 2013 datas. To solve the problems, the government has strengthening the basic health effort by conducting Program Indonesia Sehat Dengan Pendekatan Keluarga (PIS-PK). This evaluation study aimed to assess the readiness in PIS-PK implementation in several regions which have been collected more than 50% of data (OKI and Jeneponto), less than 50% (Muara Enim, Gowa, Serang) and 0% (Lebak). The methode of evaluation was qualitative through in-depth interview with the heads of district health office and the program managers and also focus group discussion with the heads and data collectors at puskesmas. The result indicates that all regions, either have or have not conducted data collection, have made planning on human resources, budgeting, and facilities. Some regions have conducted data collection despite of the limited resources. Budgeting issue is on of the problem in Lebak causing of the delay on data collection. Cross-sector support is quite good in regions, either have been conducted more than and less than 50% of data collection. Cross-sector support is not maximum in regions that have not conducted data collection. It can be concluded that despite of encountering some constraints, PIS-PK implementation is keep running. Cross-sector involvement is crucial in mobilizing the apparatus to facilitate the PIS-PK data collection.