Depression is psychological distress often occurred on cancer patient. Depression can increase perception about pain, reducing drug efficacy and longer length of stay at hospital. The objective of this study was to describe the condition of cancer patients depression who undergoing treatment at RSUP Dr. Sardjito Yogyakarta and RSUD Prof. Dr. Margono Soekarjo Purwokerto. This was a descriptive study using a cross sectional design and a pilot study. Subject were taken using non probability with purposive sampling technique. Beck Depression Inventory (BDI) was employed for selection purposes. From this study, 25,71% are experienced with mild depression, 45,71% had moderate depression and 28,58% suffered severe depression. We propose that medicine has been rated helpful by cancer patient. Psycotherapy like music therapy is part of Complementery and Alternative Medicine (CAM) can also be considered useful in lowering negative emotions beside of routine medicine like psychopharmaceutical. Doctor and Nurse can safely recommend any of these interventions for depression.